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KMID : 1007520140230010289
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Food Science and Biotechnology
2014 Volume.23 No. 1 p.289 ~ p.292
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Anti-obesity Effects of the Stem Bark of Japanese Horse Chestnut (Aesculus turbinate) in 3T3-L1 Preadipocytes
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Nam Ha-Jin
Kim Jin-Kyu
Jung Ha-rry
Suh Jun-Gyo
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Abstract
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The inhibitory effects of lipid accumulation onethanol extract from stem bark of Japanese horse chestnut(JHC) were evaluated. Exposure to JHC extract (10-100μg/mL) for a 72 h incubation period did not alter cellviability compared to the untreated control. JHC extract,with concentrations of 25, 50, and 100 μg/mL, inhibitedlipid accumulation in 3T3-L1 adipocytes in a dosedependent manner. The expression of PPARγ and C/EBPα,important adpogenic key markers was significantly reducedwhen JHC extract was added to cells for 8 days comparedwith the untreated control group. These results suggest thatJHC extract might be a potential therapeutic agent as anatural anti-obesity material.
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KEYWORD
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anti-obesity, Aesculus turbinate bark, 3T3-L1 adipocyte, lipid accumulation
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